Amoxycillin-Clavulanate

Amoxycillin-Clavuonate

Amoxycillin sodium & Clavulanate potassium for injection – 1,2 g

For  I.V. use

10 Vials per package

Each vial contains:

Amoxycillin (as the Sodium salt) – 1,0 g

Clavulanic Acid (as the Potassium salt) – 0,2 g

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Amoxycillin sodium & Clavulanate potassium for injection – 0,6 g

For  I.V. use

10 Vials per package

Each vial contains:

Amoxycillin (as the Sodium salt) – 0,5 g

Clavulanic Acid (as the Potassium salt) – 0,1 g

Amoxycillin & Clavulanic acid is a fixed semisynthetic penicillin antibiotic and ß-lactamase inhibitor combination often prescribed to provide an extended spectrum of efficacy, particularly against penicillin-resistant infections.

Amoxicillin is an analog of ampicillin (beta-lactam semisynthetic  antibiotic), derived from the basic penicillin nucleus 6-aminopenicillanic acid.

Amoxicillin acts as an irreversible inhibitor of the enzyme transpeptidase and inhibits the third, final stage of bacterial cell wall synthesis in binary fission, which ultimately leads to cell lysis.

Amoxicillin is able to penetrate Gram-positive and some Gram-negative bacteria, but it is  susceptible to degradation by ß-lactamases, and therefore, the spectrum of activity does not include organisms which produce these enzymes.

Clavulanic acid is ß-lactamase inhibitor produced by the fermentation of “Streptomyces clavuligerus”. It is a β-lactam structurally related to the penicillins and possesses the ability to inactivate a wide variety of β-lactamases by blocking the active sites of these enzymes.

Clavulanic acid is particularly active against the clinically important plasmid-mediated β-lactamases frequently responsible for transferred drug resistance to penicillins and cephalosporins.

Amoxycillin & Clavulanic acid fixed combination protects amoxicillin from degradation by ß-lactamase enzymes, effectively extends the antibiotic spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin (and other ß-lactam antibiotics) and possesses the distinctive properties of a broad-spectrum antibiotic and a ß-lactamase inhibitor.