Chloramphenicol sodium succinate – 1,0 g B.P.

Powder for injection

10 vials per package

Each vial contains:

Chloramphenicol sodium succinate equivalent to 1,0 g Chloramphenicol

Must be applied by intravenous injection over at least one minute or by slow intravenous infusion in larger volumes of fluid.

Store away from light and in a cool dry place below 250C.

Keep out of reach of children.

Chloramphenicol is a prototypical broad-spectrum bacteriostatic antibiotic, alongside the tetracyclines.

Chloramphenicol  was originally derived from the bacterium “Streptomyces venezuelae”, isolated by David Gottlieb, and introduced into clinical practice in 1949, under the trade name Chloromycetin.

Chloramphenicol was the first antibiotic to be manufactured synthetically on a large scale.

Chloramphenicol is a bacteriostatic drug that prevents protein chain elongation (stops bacterial growth by inhibiting protein synthesis) by inhibiting the peptidyl-transferase activity of the bacterial ribosome, specifically binds to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit, preventing peptide bond formation and therefore has a very broad spectrum of activity.

Chloramphenicol is active against Gram-positive bacteria (including most strains of MRSA), Gram-negative bacteria and anaerobes.

Chloramphenicol’s intravenous (IV) preparation is the succinate ester, because pure chloramphenicol does not dissolve in water.